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Luís Filipe Meira Machado Associate Professor
with Habilitation, Department of Mathematics University of Minho, Portugal |
Main
Interest Areas
·
Survival Analysis
·
Multi-state Models
·
Generalized Additive Models.
·
Nonparametric Estimation
·
Computational Statistics
·
Machine Learning
·
Copula functions
·
ROC curves
·
R programming
Work Institution
Associate
Professor with Habilitation at the Department
of Mathematics of Minho University.
Contact
Tel.:
+351 253510443/400
Fax: +351 253510401
Email: lmachado@math.uminho.pt
Adress: Department of Mathematics, University
of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
Academic
Degrees
·
BSc
in Mathematics, Minho University, July 1992.
·
MSc
in Mathematics, Lisbon University, February 1998.
· Postgraduate studies in 'Statistics' (DEA-Diploma de Estudios Avanzados), Santiago de Compostela University, September 2002.
·
PhD
in Statistics Santiago de Compostela University, December 2005.
Academic Positions
· 1991-1993 Public School Teacher, “D. Sancho I” high School. Vila Nova de Famalicão, Portugal.
·
1993-1998
Junior Teaching Assistant, Department of Mathematics for Science and
Technology.
·
1998-
Senior Teaching Assistant, Department of Mathematics for Science and
Technology.
·
1993-
2002 Member of the Mathematics Research Centre, University of Minho, Portugal.
·
2002-
Member of the Research Centre Officina Mathematica,
University of Minho, Portugal.
·
2006-2009
Assistant Professor, Department of Mathematics for Science and Technology of
Minho University.
·
2009-
Assistant Professor, Department of Mathematics and Applications.
·
2021-
Associate Professor with Habilitation, Department of
Mathematics.
Teaching Experience
·
Tutorials
on Linear Algebra and Analytical Geometry, Analysis, Advanced Analysis, and
Statistics, to first
degree Engineering Courses, University of Minho, Portugal.
·
Lectures
on Analysis to first degree Engineering Courses, University of Minho, Portugal.
·
Lectures
on Survival Analysis to the course “Specialization on decision support
techniques: Statistics and
Operational Research”, University of Minho, Portugal (2003).
·
Lectures
on Nonparametric tests to the course “Specialization on decision support techniques:
Statistics and
Operational Research”, University of Minho, Portugal (2003).
·
Lectures
on Survival Analysis to the Master “Master de Bioestadística,
USC”.
·
Lectures
on Survival Analysis, Epidemiological data analysis and Mathematical
Statistics, to the first degree course in Applied Mathematics. Lectures on Computational Statistics to the
Master “Mestrado
em Estatística para a Ciência de Dados”.
·
Professor,
Master in Statistics, Department of Mathematics for Science and Technology,
where he taught the following courses: Analysis of Clinical and Epidemiological
Data, Survival Analysis, Computational Statistics.
·
Professor
of the first Degree course in Applied Mathematics where he taught the following
courses: Epidemiologic Data Analysis, Survival Analysis, Statistical
Mathematics, Temporal and Spatial Statistics.
·
Teacher
of the First Degree Course in Applied Statistics where he taught the following
courses: Methods in Biostatistics, Statistics and Probability 2, Oficina 2, Oficina 3, Stochastic
Processes, etc.
·
Teacher
of the Master Course in Statistics where he taught the following courses:
Survival Analysis, Computational Statistics, Mathematical Statistics,
Statistical Inference, Bayesian Statistics and Applications, Theory of
Statistical Learning.
Current Research Work
[article] Luís Meira-Machado, Jacobo de Uña-Álvarez and Carmen Cadarso-Suárez. Nonparametric estimation of transition probabilities
in a non-Markov Illness-death Model. Lifetime Data Analysis 2006,
12:325-344.
[article] Luís Meira-Machado,
Carmen Cadarso-Suárez and Jacobo
de Uña-Álvarez. tdc.msm: An
R library for the analysis of multi-state survival data. Computer
Methods and Programs in Biomedicine 2007, 86:131-140.
[article] Jacobo de Uña-Álvarez and Luís Meira-Machado. A simple estimator
of the bivariate distribution function for censored gap times. Statistics
and Probability Letters 2008, 78:2440-2445.
[article] Luís Meira-Machado, Jacobo de Uña-Álvarez, Carmen Cadarso-Suárez, Per Kragh
Andersen. Multi-state models for the analysis of time to event data”. Statistical
Methods in Medical Research, 2009, 18:195-222.
[article] Carmen Cadarso-Suárez, Luís Meira-Machado, Thomas Kneib and Francisco Gude. Flexible hazard
ratio curves for continuous predictors in multi-state models: a P-spline approach. Statistical Modelling, 2010, 10:291-314.
[article] Luís Meira-Machado, Jacobo de Uña-Álvarez, Carmen Cadarso-Suárez. Inference in the progressive three-state model.” International Journal of
Mathematical models and Methods in Applied Sciences,
2008, 2:447-454.
[article] Ana Paula
Amorim, Jacobo de Uña-Álvarez, Luís Meira-Machado. Presmoothing the
transition probabilities in the illness-death model, Statistics
& Probability Letters, 2011, 81(7), 797-806
[article] Luís
Meira-Machado and Javier Roca-Pardiñas.
p3state.msm: Analyzing survival
data from an illness-death model. Journal
of Statistical Software, 2011, 38(3), 1-18.
[article] Ingrid
Van Keilegom, Jacobo de Uña-Álvarez and Luís Meira-Machado. Nonparametric location-scale models for
successive survival times under dependent
censoring. Journal
of Statistical Planning and Inference, 2011, 141: 1118-1131.
[article] Luís Meira-Machado. Inference for non-Markov multi-state
models: An overview. Revstat Volume 9, Number 1, March 2011.
[article]
Luís Meira-Machado. O
estimador de Kaplan-Meier: Novos desenvolvimentos e aplicações no contexto da
análise de sobrevivência multiestado. Boletim
SPE,
Outono 2011, 56-62.
[article] Ana Moreira and Luís Meira-Machado. survivalBIV:
Estimation of the Bivariate Distribution Function for Sequentially Ordered
Events Under Univariate Censoring. Journal
of Statistical Software, 2012, 46(13), 1-16.
[article] Luís Meira-Machado and
Susana Faria. A
simulation study comparing modeling approaches in an illness-death multi-state
model. Communications in Statistics -
Simulation and Computation. 2014, 43(5): 929-946.
[article] Luís Meira-Machado,
Javier Roca-Pardiñas, Ingrid Van Keilegon
and Carmen Cadarso-Suárez. Bandwidth
selection for the estimation of transition probabilities in the location-scale
progressive three-state model. Computational Statistics: Volume 28, Issue
5 (2013), 2185-2210.
[article] Ana Moreira,
Jacobo de Uña-Álvarez and
Luís Meira-Machado. Presmoothing the Aalen-Johansen estimator of transition
probabilities. Electronic Journal of Statistics. Volume 7 (2013), 1491-1516.
[article] Luís
Meira-Machado, Carmen Cadarso-Suárez,
Francisco Gude and Artur Araújo. smoothHR:
an R package for pointwise nonparametric estimation of hazard ratio curves of
continuous predictors. Computational and Mathematical Methods in Medicine. vol. 2013, Article ID 745742, 11 pages, 2013.
doi:10.1155/2013/745742.
[article]
Carla Moreira, Jacobo de Uña-Álvarez and Luís Meira-Machado. Nonparametric
regression with doubly truncated data. Computational
Statistics and Data Analysis. Volume 93, January
2016, Pages 294–307. http://dx.doi.org/10.1016/j.csda.2014.03.017.
[article] Artur Araújo, Luís Meira-Machado, Javier Roca-Pardiñas. TPmsm: Estimation of the transition probabilities in 3-state models. Journal of Statistical Software. 62(4).
[article] Luís Meira-Machado, Jacobo de Uña-Álvarez and Somnath Datta. Nonparametric Estimation of Conditional Transition Probabilities in a non-Markov Illness-death Model. Computational Statistics, 2015, 30:377-397. DOI: 10.1007/s00180-014-0538-6.
[article] Jacobo de Uña-Álvarez and Luís Meira-Machado. Nonparametric estimation of transition probabilities in the non-Markov illness-death model: a comparative study. Biometrics. DOI: 10.1111/biom.12288. Volume 71, Issue 2, pages 364–375, June 2015.
[article] María Xosé Rodríguez-Álvarez, Luís Meira-Machado, Emad Abu-Assi, Sergio Raposeiras-Roubín. Nonparametric estimation of time-dependent ROC curves conditional on a continuous covariate. Statistics in Medicine. 2016, 35(7):1090-1102. doi: 10.1002/sim.6769.
[article]
Luís Meira-Machado, Marta Sestelo, Andreia Gonçalves.
Nonparametric
estimation of the survival function for ordered multivariate failure time data:
a comparative study. Biometrical Journal. Volume 58, Issue 3, pages
623-634, May 2016.
[article] Marta Sestelo, Nora M. Villanueva, Luis Meira-Machado and
Javier Roca-Pardiñas. FWDselect: An R Package for Variable Selection in
Regression Models. R Journal. Volume 18, Issue 1, pages 132-148, 2016.
[article] Luís Meira-Machado. Smoothed landmark estimators of the transition probabilities. SORT 40 (2) July-December 2016, 1-24.
[article] Luís Meira-Machado and Marta Sestelo. condSURV: An R Package for the Estimation of the Conditional Survival Function for Ordered Multivariate FailureTime Data, R Journal. Volume 8, Issue 2, pages 460-473, 2016.
[article]
Ana Moreira, Artur Araújo and Luís Meira-Machado. Estimation
of the bivariate distribution function for censored gap times. Communications in
Statistics – Simulation and Computation, DOI:10.1080/03610918.2014.963609. 2017, 46(1), 275-300.
[article] Irantzu
Barrio, Maria Xosé Rodríguez-Álvarez, Luis Meira-Machado, Cristobal Esteban,
Inmaculada Arostegui. Comparison
of two discrimination indexes in the polycothomisation of continuous predictors
in time-to-event studies. SORT,
Volume 41 (1), January-June 2017.
[article] Marta
Sestelo, Nora Villanueva, Luís Meira-Machado, Javier Roca-Pardiñas, "npregfast: An R Package
for Nonparametric Estimation and Inference in Life Sciences", Jornal
of Statístical Software, 2017, 82(12), pages 1-27.
[article] Carla Moreira, Luís
Meira-Machado, Maria João
Fonseca, Ana Cristina Santos. Body mass index transitions during childhood: a multiple-state model
approach. Revue
d'Épidémiologie et de Santé Publique, Volume 66, Supplement
5, July 2018, Page S274.
[article] D. Costa, Helena Silva,
A. Célia Caetano, Luís Meira-Machado, C. Rolanda, R. Gonçalves, D. Fernandes. Effectiveness of a practical nutritional intervention in
advanced liver disease: A prospective study. Journal of Hepatology 68:S470-S471 · April 2018.
[article]
Carla Moreira, Luís Meira-Machado, Maria João Fonseca, Ana Cristina Santos. A multi-state
model for analysing transitions between body mass
index categories during childhood - Generation XXI birth cohort study. American Journal of Epidemiology, 2019, 188(2),
305-313.
[article]
José Ferreira, Nannan Song,
Margarida Machado; Luís Meira-Machado, André Correia, Ana Reis. Fatigue and microgap
behaviour of a three-unit implant-fixed dental
prosthesis combining conventional and dynamic abutments. Journal of Medical
Engineering and Technology, 2018, 42(5), 397-405.
[article] Luís Meira-Machado, Gustavo Soutinho. Análise
de Dados Multiestado: aplicação a uma base de dados de cancro da mama. Boletim
SPE, 2019, 21-29.
[article]
Nora Villanueva, Marta Sestelo,
Luís Meira-Machado. A
Method for Determining Groups in Multiple Survival Curves. Statistics in Medicine, 2019,
38(5), 866-877.
[article] Luís Meira-Machado, Marta Sestelo, Estimation
in the progressive illness-death model: a nonexhaustive
review. Biometrical Journal, 2019, Volume 61, Issue 2, 245-263.
[article]
Gustavo Soutinho,
Luís Meira-Machado. Estimation of the Transition
Probabilities in Multi-state Survival Data: New Developments and Practical
Recommendations, WSEAS Transactions on Mathematics, 2020, Volume 19, 353-366.
[article]
Paula Lopes, Pedro
Campos, Luis Meira-Machado. Survival Analysis of
Organizational Networks - An Exploratory Study, arXiv 2020, http://arxiv.org/abs/2005.01481.
[article] Gustavo Soutinho
e Luís Meira-Machado, "Some of the most common copulas for
simulating complex survival data", International
Journal of Mathematics and Computers in Simulation, ISSN: 1998-0159, Volume
14, 2020. DOI: 10.46300/9102.2020.14.5
[article] Joana Ferreira, Alexandre Carneiro, Pedro Cunha, Armando Mansilha, Isabel Vila, Cristina Cunha, Cristina Silva, Adhemar Longatto-Filho, Maria Correia-Neves, Gustavo Soutinho, Luís Meira-Machado, Amilcar Mesquita, Jorge Cotter, "Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?", Artery Research, , Volume 26, 2020. DOI: https://doi.org/10.2991/artres.k.201209.072
[article]
Ana Paula Amorim, Emília Athayde, Cecília Castro,
Marta Susana Ferreira, A Manuela Gonçalves, Raquel Menezes, Maria Conceição
Serra, Susana Faria, Luís Meira-Machado, Inês Sousa, Carla Maria Gonçalves
Macedo Moreira. "UM departamento com ESTATÍSTICA", Boletim SPE, Outono 2020, 44-47.
[article] Susana Pedras, Luís Meira-Machado, André
Couto-Carvalho, Rui Morais Carvalho, M. Graça Pereira, "Anxiety And/Or
Depression: Which Symptoms Contribute to Adverse Clinical Outcomes After Amputation?", Journal of Mental Health, 2020. https://doi.org/10.1080/09638237.2020.1836554
[article] Nora M.
Villanueva, Marta Sestelo, Luis Meira-Machado
and Javier Roca-Pardiñas. clustcurv:
An R Package for Determining Groups in Multiple Curves. R
Journal, Vol. 13/1, June
2021.
[article] José Ferreira,
Luís Meira-Machado, José Manuel Oliveira, João Carlos Ramos. Effect of crown-to-implant
ratio and crown height space on marginal bone stress: A finite element
analysis. International Journal of
Implant Dentistry, 2021 https://doi.org/10.1186/s40729-021-00368-1.
[article] Gustavo Soutinho, Marta Sestelo, Luis Meira-Machado. survidm: survidm: An R package for Inference and Prediction in an Illness-Death Model. R Journal, 2021, 13:2, 70-89. https://doi.org/10.32614/RJ-2021-070.
[article]
Gustavo Soutinho,
Luís Meira-Machado, Pedro Oliveira. A
comparison of presmoothing methods in the estimation of transition probabilities. Communications in Statistics - Simulation and
Computation, 2022, 51(9), 5202–5221.
DOI: 10.1080/03610918.2020.1762895.
[article] Gustavo Soutinho,
Luis Meira-Machado. Methods for checking
the Markov condition in multi-state survival data. Computational Statistics,
2022. https://doi.org/10.1007/s00180-021-01139-7.
[article] Gustavo Soutinho,
Luís Meira-Machado, Analysis
of Complex Survival Data: a tutorial using the Shiny MSM.app
application, arXiv 2022, https://arxiv.org/abs/2202.09160 https://doi.org/10.32614/RJ-2021-070.
[article] José Ferreira,
Luís Meira-Machado. Insertion torque value and implant stability quotient: Separate
evaluation and correlation for different clinical parameters. International Journal of
Oral & Maxillofacial Implants,
2022, 37(4), 812-822. 10.11607/jomi.9346
[article]
Javier Roca-Pardiñas,
Celestino Ordóñez, Luís Meira-Machado. A
method for determining groups in nonparametric regression curves: application
to prefrontal cortex neural activity analysis. Mathematical Biosciences and
Engineering, 2022. Volume 19, Issue: 6435-6454. doi: 10.3934/mbe.2022302
[article] Gustavo Soutinho, Luís Meira-Machado. Parametric
landmark estimation of the transition probabilities in survival data with
multiple events, WSEAS Transactions on Mathematics, 2022, Volume 21, 207-217.
doi: 10.37394/23206.2022.21.27
[article] Gustavo
Soutinho, Luis Meira-Machado. Nonparametric
estimation of the distribution of gap times for recurrent events. Statistical
Methods and Applications, 2023. https://doi.org/10.1007/s10260-022-00641-6
[article] Luis Meira-Machado, Carla Moreira, Gustavo Soutinho, Marta Azevedo, Analysis
of survival data with multiple events: application to a breast cancer database.
WSEAS Transactions on Mathematics. 2022, Volume 21: 854-863. doi: 10.37394/23206.2022.21.97
[article]
Maria Graça Pereira; Margarida
Vilaça; Susana Pedras; André Couto Carvalho; Kavita Vedhara; Maria Jesus Dantas; Luís Meira-Machado. Wound
Healing and Healing Process in Patients with Diabetic Foot Ulcers: A Survival
Analysis Study. Diabetes Research and Clinical Practice. Vol 128 Abril 2023. https://doi.org/10.1016/j.diabres.2023.110623
[article] Gustavo Soutinho, Luis Meira-Machado. markovMSM: An R package for checking the Markov condition
in multi-state survival data. R Journal. (2023) Accepted
[Book Chapter] N. Amorim, A. Ferreira, L. Meira-Machado,
“Micro-analysis of mortality in urban areas: The parish of Oliveira in Guimarães between the 18th and 20th centuries”. Title of
the book “New Approaches to Death in Cities During the Health Transition”,
Editors names: Diego Ramiro Fariñas and Michel Oris, Springer-Verlag, 2016
(pages 77-96). ISBN 978-3-319-43002-7.
[Books] Luís Meira-Machado e Gustavo Soutinho,
“Proceedings of the 34th International Workshop on Statistical Modelling Volume
I”, 2019 (332 páginas). ISBN: 978-989-20-9528-8.
[Books] Luís Meira-Machado e Gustavo Soutinho, “Proceedings of the 34th International Workshop on Statistical Modelling Volume II”, 2019 (444 páginas). ISBN: 978-989-20-9630-8
[Books] Arminda Gonçalves, Inês Sousa, Luís Meira-Machado, Raquel Menezes, Susana Faria. XX Jornadas de Classificação e Análise de Dados (JOCLAD2013) – Livro de Resumos (ISBN: 978-989-20-3771-4). Produzido por Instituto Nacional de Estatística.
[Books] Arminda Gonçalves, Inês Sousa, Luís
Meira-Machado, Paulo Pereira, Raquel Menezes, Susana Faria. (2012). Programme and Book of Abstracts - VI
International Workshop on Spatio-Temporal Modelling.
[CD-ROM]
Arminda Gonçalves, Inês Sousa, Luís Meira-Machado, Paulo Pereira, Raquel
Menezes, Susana Faria. CD-ROM with Proceedings of the VI International
Workshop on Spatio-Temporal Modelling (ISBN:
978-989-97939-0-3).
[Book Chapter] Pedro Campos, Paula Lopes, Luís
Meira-Machado, Gustavo Soutinho
“Survival Analysis of Organizational Network – An exploratory study”. Lecture
Notes in Computer Science, Computational Science and its Applications - ICCSA
2023 Workshops, volume 14112, 117-128, Springer, 2023. https://doi.org/10.1007/978-3-031-37129-5_10
[Book Chapter] Luís Meira-Machado, “The Kaplan-Meier estimator: new insights
and applications in multi-state survival analysis”. Lecture Notes in Computer
Science, Computational Science and its Applications - ICCSA 2023 Workshops,
volume 14112, 129-139, Springer, 2023. https://doi.org/10.1007/978-3-031-37129-5_11
Talks and Presentations
[talk] “Flexible
modelling of hazard ratio curves in Multi-state
Models”. Departamento de Matemática para a Ciência e Tecnologia. University of Minho, Portugal. February 2008.
[invited] “Inference
in multi-state survival data”. Invited Speaker in II Mathematical Iberian
Meeting. Spain, Badajoz, 3-5th October 2008.
[chair] “Meeting SPE/CIM, com a colaboração do CEAUL,
in Survival Analysis”, Lisboa, Portugal, November 27,
2009.
[invited] “New methods in multi-state models: the three-state
model”. Invited Speaker of the workshop StaM2010 “Statistical
Modelling: Challenges in Health”, Lisboa,
Portugal, 9-12 May 2010.
[talk] “Inference in the progressive
three-state model”. Departamento
de Estatística e Investigação Operacional. University of Vigo, Spain. September 2010.
[invited] “New
methods for the analysis of multi-state survival data”. Applied Stochastic Models and Data Analysis
(ASMDA2011). Special Session: Event Time Data Analysis. Rome, Italy,
7-10 June 2011
[talk] “An R Package
for the inference in a multi-state illness-death model”, III Jornadas de Usuários
de R, Madrid, Espanha, November 17-18, 2011.
[invited] “Presmoothing the Aalen-Johansen in an illness-Death
model”, Invited talk in the 4th
International Conference of the ERCIM Working Group on Computing &
Statistics, London, England, December 17-19, 2011.
[talk] “Estimation of
Conditional Transition Probabilities in a non-Markov Illness-death Model”, 8th
World Congress in
Probability and Statistics, Istanbul, Turquey, July
9-14, 2012.
[invited] “Estimation of conditional
transition probabilities in non-Markov multi-state models”, Invited talk in the 5th International Conference of the ERCIM Working Group on Computing & Statistics, Oviedo, Spain, December 1-3, 2012.
[invited] “Dynamic prediction for
multi-state survival data”, Invited talk in the 29th European Meeting
of Statisticians,
Budapest, Hungry, July 20-25, 2013.
[invited] “Estimation of the transition probabilities in the
illness-death model”, 7th International Conference of the ERCIM WG on
Computational and Methodological Statistics (ERCIM 2014), Pisa, Italy, 6-8
December, 2014.
[invited] “Nonparametric estimation of the conditional survival
function for ordered multivariate failure time data”, Invited talk in the 8th International Conference of the ERCIM Working Group on Computing
& Statistics, London, England, December 12-14, 2015.
[invited] “Estimation of multivariate distributions in censored
gap times”, Invited talk in the 9th International Conference of the ERCIM
Working Group on Computing & Statistics, Seville, Spain, December 9-11,
2016.
[invited]
“Modelos matemáticos para análise da epidemiologia de delirium", 12º Congresso Nacional de Psiquiatria,
Vilamoura, Portugal, November 9-12.
[invited] “A utilização da
(Bio)Estatística em problemas de Investigação das Ciências da Saúde”, 2º
Encontro de Ciência, 3-4 de Março de 2017, Vila Nova de Famalicão (http://eccmfamalicao2017.wixsite.com/cfaevnf)
[invited] “Estimation of the
transition probabilities in non-Markov models: new contributions and software
development”, 38th Annual Conference of the International Society for Clinical
Biostatistics, Vigo, Spain, July 9-13, 2017.
URL: http://iscb2017.info/?fwp=10&fwl=2.
[invited] Dynamic predictions in
multi-state models: the illness-death model, “V WASA - Workshop em Análise de Sobrevivência
e Aplicações”. Universidade Federal da Bahia,
Salvador, Brasil, 28 de Fevereiro a 2 de Março de 2018. URL: http://www.redeabe.org.br/wasa2017/paginas/conferencias-.
[invited] “Analysis of survival data with
multiple events: the illness-death model”,
One Day Meeting on
Statistics and Applied Probability, Universidade do Minho, Guimarães,
Portugal, 4 de Outubro de 2019.
[invited] “Methods for checking the Markov
condition in multi-state survival data”,
12nd International Conference of the ERCIM WG on Computational and
Methodological Statistics (ERCIM 2019), session “New methodologies and
advances in survival and reliability” (organized by Juan Eloy Ruiz-Castro), University of London, 14-16 December 2019.
[invited] “Estatística
em investigação clínica”. Mesa II: A organização do processo de
investigação clínica. I Jornadas de Investigação Clinica e Atividade
Científica. Guimarães, Portugal em 22 de junho de 2021.
[invited] “Analysis of Multistate
time-to-event data: practical recommendations and implementation”, 24th International
Conference on Computational Statistics (COMPSTAT 2022) session “Multistate
Models and Intermediate Events” (organized by Martina Mittlboeck).
Bolonha, Itália. 23-26 de
Agosto de 2022.
[invited] "Contributions in
Statistical Modelling with Applications in Biomedicine", 5th Biostatnet Meeting session “Tribute to Carmen Cadarso Suárez” (organized by Javier Roca Pardiñas). Santiago de Compostela,
Espanha. 19-20 de janeiro
de 2023.
· An R package, called survidm developed to provide estimation of several quantities of interest in multi-state models (transition probabilities, occupation probabilities, cumulative incidence functions and sojourn distributions). https://CRAN.R-project.org/package=survidm
· An R package, called condSURV developed to provide the estimation of the
conditional survival function.
· An R package, called TP.idm developed to provide the estimation of
transition probabilities for the illness-death model.
· An R package, called p3state.msm
developed for the analysis of the illness-death multi-state survival data.
· An R package, called survivalBIV developed for the estimation of the bivariate
distribution function for sequentially ordered events under univariate
censoring.
· An R library, called tdc.msm, developed for the
analysis of multi-state survival data.
· An R library, called genSurv, for the generation of survival data arising
from a progressive illness-death model.
· An R library called TPmsm, for obtaining estimates of the transition
probabilities in 3-state multi-state models.
· An R library called smoothHR, for obtaining flexible hazard ratio curves
with confidence bands when considering a reference value.
· An R package called presmTP,
for obtaining presmoothed estimates of the transition
probabilities.
· An R package called markovMSM,
for checking the Markov condition in multi-state survival data.
· Software
developed for SIC Portuguese Television (with Fernando Fontes and Paulo Pereira).
Proceedings
[i]. Luís Meira-Machado, Carmen Cadarso-Suárez, Jacobo de Uña-Àlvarez, “Alternatives to the Cox model in Multi-state models”. I Congresso de Estatística e Investigação Operacional da Galiza e Norte de Portugal VII Congreso Galego de Estatística e Investigación de Operacións; Guimarães, Portugal, 2005.
[ii]. Luís Meira-Machado, “Estimation of transition probabilities in multi-state survival data”. International Conference on Interdisciplinary Mathematical & Statistical Techniques, Tomar, Portugal, 2006.
[iii]. Luís Meira-Machado, “Análise de dados de cancro do intestino utilizando modelos de estados múltiplos”. XIV Congresso Anual da Sociedade Portuguesa de Estatística, Covilhã, Portugal, 2006.
[iv]. Luís Meira-Machado and Jacobo de Uña-Álvarez, “Estimation of the bivariate distribution function for censored gap times”. XI Conferência Espanhola e Primeiro Encontro Ibero Americano de Biometria, Salamanca, Spain, 2007.
[v]. Luís Meira-Machado, “Inference in Multi-state survival data”. II Iberian Mathematical Meeting,
session “Statistics and Biometry”,
Badajoz, Spain, 3-5 October,
2008.
[vi]. Luís Meira-Machado,
Carmen Cadarso-Suárez and Jacobo
de Uña-Álvarez, “Inference
in Multi-state survival data”. The 13th WSEAS International Conference on
APPLIED MATHEMATICS, pp. 123-128. Tenerife, Spain, 2008.
[vii]. Luís Meira-Machado,
Javier Roca-Pardiñas, “p3state.msm: software for the analysis of multi-state survival data”.
IX Congreso Galego de Estatística
e Investigación de Operacións,
pp. 285-290. Ourense, Spain, 2009.
[viii]. Ana Moreira, Luís
Meira-Machado, “Available
software for the analysis of multi-state survival data”, XXXII Congreso Nacional de Estadística
e Investigación Operativa,
pp. 1-13. Coruña, Spain, September 14-17, 2010.
[ix]. Luís Meira-Machado,
Ana Moreira, “Estimation of the
Bivariate Distribution Function for Censored Gap Times”. 19th International
Conference on Computational Statistics, pp. 1367-1374. Paris, France, August
22-27, 2010.
[x]. Ana Moreira and Luís
Meira-Machado, “An
R Package for the Estimation of the Bivariate Distribution for Censored Gap
Times”. 26th International Workshop on Statistical Modelling (IWSM2011). Universitat de València July
11-15th, 2011.
[xi]. Norberta Amorim,
Antero Ferreira, Luís Meira-Machado,
“Micro-analysis of mortality in urban
areas The parish of Oliveira in Guimarães between the
18th and 20th century”. Seminar on New Approaches to Death in Cities during
the Health Transition, Sevilha, Spain, December
15-16, 2011.
[xii]. Ana Moreira,
Luís Meira-Machado, “Conditional Estimation of the Bivariate
Distribution Under Dependent Right Censoring”. 27th International Workshop
on Statistical Modelling IWSM'27, Prague, Czech Republic, July 16-20, 2012.
[xiii]. Ana Moreira,
Artur Agostinho Araújo, Luís Meira-Machado,
“Estimation of the Bivariate Distribution
Function: a Comparative Study”. 27th International
Workshop on Statistical Modelling IWSM'27, Prague, Czech Republic, July 16-20,
2012.
[xiv]. Ana Moreira,
Luís Meira-Machado, “Estimation of the conditional survival
function for successive survival times”. 28th International
Workshop on Statistical Modelling IWSM'28, Palermo, Italy, July 8-12, 2013.
[xv]. Andreia Gonçalves, Luís Meira-Machado, Marta Sestelo, “Estimação da Função de Sobrevivência em dados de eventos recorrentes com censura pela direita”. XXII Congresso da Sociedade Portuguesa de Estatística, Ria Formosa, 7 a 10 de Outubro de 2015.
[xvi]. Luís Meira-Machado, Marta Sestelo, Andreia Gonçalves, “Nonparametric estimation of the survival
function for ordered multivariate failure time data: a comparative study”,
Proceedings of the 30th International Workshop on Statistical Modelling
IWSM'30, Linz, Austria, July 5-10, 2015.
[xvii]. Luís Meira-Machado, “Presmoothed
Landmark estimators of the transition probabilities”. Proceedings of the
31th International Workshop on Statistical Modelling IWSM'31, Rennes, France,
July 4-8, 2016.
[xviii]. Luís Meira-Machado, “Estimation
of multivariate distributions for recurrent event data”. Proceedings of the
32th International Workshop on Statistical Modelling IWSM'32, Groningen,
Netherlands, July 2-7, 2017.
[xix]. Carla Moreira, Luís Meira-Machado,
Maria João Fonseca, Ana Cristina
Santos. Body mass index
transitions during childhood: a multiple-state model approach. Revue d'Épidémiologie et de Santé
Publique, Volume 66, Supplement 5, July 2018, Page
S274.
[xx]. Luís Meira-Machado, Marta Sestelo, “An R package for
Inference and Prediction in an Illness-Death Model”. Proceedings of the 33rd
International Workshop on Statistical Modelling IWSM'33, Bristol, UK, July
16-20, 2018.
[xxi]. Luís Meira-Machado, Marta Sestelo, “An R
package for Inference and Prediction in an Illness-Death Model”.
Proceedings of the 33rd International Workshop on Statistical Modelling
IWSM'33, Bristol, UK, July 16-20, 2018.
[xxii]. Nora M. Villanueva, Marta
Sestelo, Luís Meira-Machado, “An R
package for Determining Groups in Multiple Survival Curves”. Proceedings of the 33rd International Workshop on Statistical
Modelling IWSM'33, Bristol, UK, July 16-20, 2018.
[xxiii].
Gustavo Soutinho, Luís Meira-Machado, Pedro Oliveira, “A comparison of Presmoothing
methods in the estimation of Transition
Probabilities”, III Encontro Luso-Galaico de
Biometria (EBio2018), Aveiro, Portugal 28-30 June
2018, pp 53-56.
[xxiv]. Gustavo Soutinho, Luís Meira-Machado, Pedro Oliveira, “Methods
for checking the Markov condition in multi-state survival data”.
Proceedings of the 34th International Workshop on Statistical Modelling
IWSM'34, Guimarães, Portugal, July 7-12, 2019.
[xxv]. Carla Moreira, Luís Meira-Machado, Maria João Fonseca, Ana
Cristina Santos, “Multi-level
modelling of longitudinal child growth data: a comparison of growth models in
the Generation XXI birth cohort”. Proceedings of the 34th International
Workshop on Statistical Modelling IWSM'34, Guimarães, Portugal, July 7-12,
2019.
[xxvi]. Gustavo
Soutinho, Luís Meira-Machado, Pedro Oliveira, Estimation of the Transition
Probabilities condition on repeated measures in Multi-state models. Proceedings of the 35th International Workshop on
Statistical Modelling IWSM'35, Bilbao, Spain,
[xxvii]. Gustavo
Soutinho, Luís Meira-Machado, “Presmoothed
Estimators of the State Occupation Probabilities in Multi-state
Survival Data”. AIP Conference Proceedings, International Conference on
Numerical Analysis and Applied Mathematics 2022, ICNAAM 2022.
[xxviii]. Gustavo
Soutinho, Luís Meira-Machado, “Estimation of the Transition Probabilities
Conditional on Covariates with Repeated Measures: a
Joint Modeling Approach”. AIP Conference Proceedings, International Conference
on Numerical Analysis and Applied Mathematics 2022, ICNAAM 2022.
Other Research
Reports and Thesis
· Estudo das Categorias Extensivas e Modulares. (MSc thesis, University
of Lisbon, 1998).
·
Luís Meira-Machado, Jacobo de Uña-Álvarez, Carmen Cadarso-Suárez,
Per Kragh Andersen. Multi-state models for the
analysis of time to event data. Research Report 07/01 2007, Department of
Biostatistics, University of Copenhagen. (this
file can be downloaded from: http://biostat.ku.dk/reports/2007/researchreport07-1.pdf)
·
Ingrid Van Keilegom,
Jacobo de Uña-Álvarez and
Luís Meira-Machado. Nonparametric
location-scale models for successive survival times under dependent censoring. Discussion paper (this file can be
downloaded from: http://sites.uclouvain.be/IAP-Stat-Phase-V-VI/ISBApub/ISBAdp.html#2008).
·
Luís Meira-Machado and Javier Roca-Pardiñas.
p3state.msm: Analyzing survival data from an illness-death model. Research
Report, Department of Statistics and Operations Research, University of Vigo,
Spain.
Supervisions
[Post-doc] Carla Maria
Gonçalves Moreira, “New developments in the
statistical analysis of survival data”, started in 01/01/2011.
[Post-doc] Marta Sestelo Pérez, “New developments and software in flexible
regression models”, started in 01/09/2014.
[Post-doc] Maria Xosé Rodrigues Álvarez, beginning in September 2013, end in May 2016 (with Javier Roca-Pardiñas (Univ. Vigo) and Thomas Kneib (Univ. Göttingen)).
[PhD] Ana Cristina Moreira, “Métodos para a análise de dados
de sobrevivência multiestado”, University of Minho. Concluded
in May 2014.
[PhD] Gustavo Soutinho, “Statistical analysis of complex survival data:
new contributions in statistical inference, software development and biomedical
applications”. Concluded in july 2022.
[PhD] Marta Vasconcelos Castro Azevedo.
“Recent advances in the statistical analysis of failure time data” In progress.
[PhD] Artur Agostinho Araújo. “Novel Statistical and Computer Methods in Biomedical Research” (Programa Doutoral em Estatística e Investigación Operativa – supervision with Prof. Javier Roca Pardiñas). In progresso.
[Other] Liliana Rodrigues Coelho, “Métodos flexíveis em modelos de sobrevivência multiestado. Análise de dados de cancro da mama.” Trabalho inserido no programa de Diploma de Estudos Avançados do Departamento de Estatística e Investigación Operativa da University of Santiago de Compostela, Spain. Conclusion in July 2009.
[Msc] Alda Marisa Ribeiro Fernandes, “Análise de dados em Modelos de estados múltiplos”, Master in Statistics, University of Minho. Concluded in July 2011.
[Msc] Artur Agostinho Araújo, cujo
tema é “Estimação da função de distribuição bivariada
na presença de censura”, Master in Statistics, University of Minho. Concluded in December 2012.
[Msc] Ilídio Miguel Sousa Andrade
Pereira, cujo tema é “Atitudes face à estatística em estudantes de ciências da
saúde”, Master in Statistics, University
of Minho. Concluded in December 2012.
[Msc] Edgar Martins Mesquita,
cujo tema é “Estudos Bioestatísticos em Linfomas e Leucemias Agudas”, Master in
Statistics, University of Minho. Concluded in October 2013.
[Msc] Miguel Basto Pereira, cujo
tema é “Estimação da Sensibilidade, da Especificidade e da curva ROC”, Master
in Statistics, University of Minho. Concluded in December 2013.
[Msc] Andreia Catarina de Sousa Gonçalves, “Estimação da Função de Sobrevivência em dados de eventos recorrentes com censura pela direita”, Mestrado em Estatística, University of Minho. concluded in January 2016.
[Msc] Paula Rosa Silva Lopes, “Estudo de
sobrevivência de doentes com cancro de colo de útero”, Master in Statistics, University of Minho. Concluded in March 2017.
[Msc] Ana
Beatriz Sampaio e Castro Lapa Carneiro, “Estimação de distribuições
multivariadas na presença de censura pela direita”. Concluded
in December 2017.
[Msc] Carla
Sofia Garcia Soares Ferreira, com o trabalho “Estudo da Prevalência
das doenças lisossomais em Portugal”. Concluded in December 2018.
[Msc] Renato
Fernandes dos Santos, com o trabalho “Análise estatística a
variáveis relacionadas com as especificações de pneus e respetivos testes”. Concluded in December 2019.
[Msc] Giulia Rizzo, com o trabalho
“Analysis of survival data: German Breast Cancer Study” Concluded in July 2020.
[Msc] Yoann Folha,
“Análise de tendências e determinantes do nível de conhecimento do HIV/AIDS em
Moçambique”. Concluded in March
2021.
[Msc] João
Rego, “Avaliação de Metodologias de Controlo de Confidencialidade: uma
aplicação com bases de microdados para efeitos de
investigação”. Concluded june
2022.
[Msc] Emanuel
Vieira Monteiro da Silva, “Desenvolvimento de uma aplicação Shiny
para análise de dados de sobrevivência”. Concluded december 2022.
[Msc] Pedro Capêlo, “Florestas
Aleatórias e Árvores de Classificação e de Regressão na Análise de dados
Censurados”.
Concluded December 2022.
[Msc] Rodrigo
Filipe Rodrigues Rocha, com o trabalho “Classificação de Preferências
Alimentares no Retalho Alimentar: um Abordagem Supervisionada”. Ongoing.
[Msc] Paulo
Jorge Lamoso Laranjeira, com o trabalho “Tutorial sobre a utilização de
software estatístico para a implementação de modelos multiestado e de riscos
competitivos”. Ongoing.
[Msc] Leandro
dos Santos Xavier Duarte, com o trabalho “Improved
time estimation in Covid19 progression”.
Ongoing.
LiDA
(Lifetime Data Analysis).
JIRSS
(Journal of the Iranian Statistical Society).
JSS (Journal
of Statistical Software).
AISM (Annals of the
Institute of Statistical Mathematics).
SPE (Sociedade Portuguesa de Estatística).
JCS (Journal
of Computational Statistics).
SRE (Scientific Research and Essays).
SPL (Statistics & Probability Letters).
JBD (Journal of Biological Dynamics).
SMMR
(Statistical Methods in Medical Research)
BIOM (Biometrics)
BIOMJ (Biometrical Journal)
CSSC
(Communications in Statistics - Simulation and Computation)
CISTI
(Iberian Conference on Information Systems and Technologies)
REVSTAT
TEST
SJS
(Scandinavian Journal of Statistics)
SAJ
(Scandinavian Actuarial Journal)
ISNPS (International Society
for NonParametric Statistics)
The R
Journal
BMC
Medical Research Methodology
Acta Medica
Portuguesa
Experiences in the organization of activities I+D
Chair of the 34th edition of the International
Workshop on Statistical Modelling (IWSM2019 – www.iwsm2019.org), July 7-12 2019, Guimarães, Portugal.
Secretary and Treasurer of
the Organizing Committee for the “I Congresso de
Estatística e Investigação Operacional da Galiza e Norte de Portugal VII Congreso Galego de Estatística e Investigación
de Operacións, Guimarães, Portugal, October 26-28, 2005”.
Member of the organizing committee of the “XI Conferência Espanhola e Primeiro Encontro Ibero Americano de Biometria”, Salamanca, Spain, July 20- 22, 2007”.
Member of the
scientific committee of the workshop StaM2010 “Statistical Modelling: Challenges in Health”,
Lisbon, Portugal, May 9-12, 2010.
Organization of the invited session “Modelos Multiestado”
from the Conference SEIO (Sociedad Española de Estadística e Investigación Operativa), A Coruña, Spain,
September 14-17, 2010.
Member of the
organizing committee of the workshop “VI International Workshop on Spatio-Temporal Modelling (METMAVI)”, Guimarães,
Portugal, September 12-14, 2012.
Member of the scientific committee of the workshop “1.º Fórum de Estatística na Universidade do Minho”, NEEUM, School of Sciences, University of Minho, Guimarães, Portugal, September 25th 2012.
Member of the
organizing committee of the workshop “Workshop Statistical Modelling in Medical and Environmental Sciences”, Guimarães,
Portugal, December 13, 2012.
Member of the
organizing committee of the Conference “JOCLAD 2013 - XX Jornadas
de Classificação e Análise
de Dados”, Guimarães, Portugal, April 11-13,
2013.
Member of the
organizing committee of the workshop “Second Meeting on Statistical Modeling in
Medical and Environmental Sciences”, Guimarães,
Portugal, October 3-4, 2013.
Member of the scientific committee of the Conference “I Encontro Português de Biometria e I Encontro Luso-Galaico de Biometria”, Braga, Portugal, July 14-16, 2013.
Member of the
organizing committee of the workshop “Second Meeting on Statistical Modeling in
Medical and Environmental Sciences”, Guimarães, Portugal,
October 3-4, 2013.
Member of the
organizing committee of the workshop “Statistics and
Applications”, Guimarães, Portugal, October 15-16, 2014.
Organization of the invited session “New
software developments for competing risks and multi-state models” of the Conference ERCIM 2014,
Pisa, Italy, December 6-8, 2014.
Member of the
scientific committee of the workshop “One-Day Workshop on Statistics Analysis”, Lisbon, Portugal, January 27, 2017.
Member of
the scientific committee of the “33rd International Workshop on Statistical Modelling”, Bath, England,
July 2018.
Chair of
the “34rd International
Workshop on Statistical Modelling”, Guimarães,
Portugal, July 2019.
Member of
the scientific committee of the “35th International Workshop on Statistical Modelling”, Bilbao, Spain,
July 2020.
Member of
the scientific committee of the “25th National Congress of the Portuguese Statistical Society”,
November 2020.
Vice-Presidente
da Comissão Organizadora do “XXVI Congresso da Sociedade Portuguesa de
Estatística”, Guimarães, Portugal, Outubro de 2023. URL: https://w3.math.uminho.pt/SPE2023/comissoes.html#
Membro e co-chair da Comissão Científica do “One-Day Meeting On Survival Analysis”, Guimarães, Portugal, Julho de 2023. URL: https://w3.math.uminho.pt/ODMSurvivalAnalysis/
Membro da
Comissão Científica do “XXVI Congresso da Sociedade Portuguesa de Estatística”,
Guimarães, Portugal, Outubro de 2023. URL: https://w3.math.uminho.pt/SPE2023/comissoes.html#
Membro da
Comissão Organizadora do “International Symposium on NonParametric
Statistics (ISNPS)”, Guimarães, Portugal,
junho de 2024. URL: https://w3.math.uminho.pt/ISNPS2024/index.html#
Membro da
Comissão Científica do “International Symposium on NonParametric
Statistics (ISNPS)”, Guimarães, Portugal,
junho de 2024. URL: https://w3.math.uminho.pt/ISNPS2024/index.html#
Coordination of Projects / Funding
[Member] Project “PREFERENTIAL - Improving spatial estimation and survey design through preferential sampling in fishery and biological applications”. FCT - Programa 2017 - 02/SAICT/2017. Projeto com referência PTDC/MAT-STA/28243/2017. Investigador principal: Raquel Menezes.
[Member] Project “Contribuição dos Fatores
Psicológicos na Cura da Ulcera do Pé Diabético, em Indicadores Fisiológicos de
Prognóstico de Cura, e Qualidade de Vida: Um Estudo Longitudinal Randomizado de
Avaliação de Eficácia”. Projeto FCT 2017 (H2020) com referencia
02-SAICT-2017 (FCT). Investigador Principal: Maria da Graça Pereira Alves. Project funded with 187.915,67 €
[Member] Project “New contributions in semiparametric regression and
applications in agricultural field trials, epidemiological risk assessment, and
marine ecology”. Ministerio de Economía, Industría y Competitividad (Espanha)
referencia MTM2017-82379-R. Investigador principal: María Xosé
Rodríguez ÁLvarez e Dae-Jin
Lee. Project funded
with 50.000,00 euros. 2018 - 2020.
[Member] Project “Inferencia en Modelos Aditivos Generalizados: Extensiones al Analisis ROC con Covariables, Regresion Cuantil y Analisis de Supervivencia. Aplicaciones en Medicina y Biologia”. Ministerio de Educación y Ciencia (Espanha) MTM2011-28285-C02-01. Fondos FEDER (Conv. Publica). Investigador principal: Carmen Cadarso Suárez. Project funded with 96.558,00 euros. 2012 - 2014.
[Member]
Project “Espaços urbanos: dinâmicas demográficas e sociais (séculos
XVII-XX)”, with reference
PTDC/HIS-HIS/099228/2008. Project financed with 142.989,00 euros. Beginning in March 2010.
Principal Researcher: Carlota Maria Fernandes Santos.
Duration: 18 months.
[Member] Project “Formación
de una Red Nacional de Bioestadística”.
Ministerio de Ciencia e Innovación (Espanha)
MTM2010-09213-E. Principal Researcher: Carmen Cadarso
Suárez. Duration: 12 months.
[Member] Project “Census Vivo”, ciência viva VI with reference CV/PVI/0782 Portugal (with
conclusion in 2007). Principal Researcher: Bruno Sousa. Project financed with 25.000 euros.
[Member] Project “Elemento do projeto “Inferencia Estadística en Modelos Aditivos Generalizados y Extensiones. Aplicaciones a la Fisiología, Epidemiología y Radiología”. Ministerio de Educación y Ciencia (Espanha). Fondos FEDER (Conv. Publica). Investigador principal: Carmen Cadarso Suárez. Project funded with 56.900 euros. 2005- 2017.
Statistics and Operational Research
Department in Santiago de Compostela University,
where I was registered as a PhD student and where my official supervisor Prof.Carmen Cadarso-Suárez. My
other official PhD supervisor is Prof. Jacobo de Uña-Álvarez from Vigo University.
·
IWSM2019
·
International
Association for Statistical Computing, IASC-ISI
· Associação Portuguesa de Classificação e Análise de Dados, CLAD
· Sociedade Portuguesa de Estatística, SPE
· R
· Quick-R
· Statistics Calculator Online
·
Wolfram Research: Probability
and Statistics, Integral
Calculator, Derivative
Calculator
·
Diagnostic
Test Evaluation Calculator
·
Statistical Computation Online:
Clinical Calculator and many other tests
·
Compendium
of Common Probability Distributions